[Theoretical approach to the description of microvesicular transport in the endothelium]

Theoretical consideration of mechanisms on curvature of the cell membrane, resulting in formation of microvesicles in the cells has been carried out. These mechanisms are presented as: 1) local changes of membrane surface tension at the border membranes--external medium; 2) local changes of the membrane potential; 3) hydrostatic pressure; 4) crystallization of membrane domains; 5) enzymatic changes of the lipid molecule configurations. Energy of the curved membrane and the energy of the external effects for the vesicle are estimated. Spontaneous formation of vesicles at the expense of the oscillatory mechanism is impossible. The most probable mechanism, from the energetic point of view, for vesicular formation is adsorption of surface-active substances or ions on the membrane. Thus, the processes of microvesicular mass transfer, playing an important role in transcapillary mass exchange are determined by physicochemical mechanisms. From the physico-chemical point of view adsorption of substances can be the most probable mechanism in the vesicular formation and determine intensity of vesicular transport.