Related Experiment Video

Updated: Dec 26, 2025

The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers
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The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers

Published on: January 22, 2013

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The (pro)renin receptor: a novel biomarker and potential therapeutic target for various cancers

Juan Wang1,2, Akira Nishiyama3, Makoto Matsuyama4

  • 1Department of Medical Oncology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. wangjuan2@zju.edu.cn.

Cell Communication and Signaling : CCS
|March 8, 2020
PubMed
Abstract

Insights

The (pro) renin receptor ((P)RR) is increasingly recognized for its role in various cancers. This review highlights (P)RR's involvement in tumorigenesis and its potential as a diagnostic and therapeutic target.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • The (pro) renin receptor ((P)RR) is implicated in tumorigenesis through pathways like Wnt/β-catenin and RAS.
  • (P)RR's role in cancer development is a recent discovery, expanding beyond its known functions in cardiovascular and renal systems.
  • Aberrant (P)RR expression contributes to various cancers, including pancreatic, colorectal, brain, endometrial, and glioblastoma.

Purpose of the Study:

  • To review the newly recognized roles of (P)RR in cancer pathophysiology.
  • To summarize (P)RR's functions in cancer development via related signaling pathways.
  • To present novel research on (P)RR detection and therapeutic applications.

Main Methods:

  • Analysis of big data from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases.
  • Comprehensive review of recent studies on (P)RR in cancer.
  • Exploration of research on soluble (P)RR detection kits and monoclonal antibodies.

Main Results:

  • This review consolidates evidence on (P)RR's essential roles in tumorigenesis and cancer progression.
  • Detailed functions of (P)RR through associated signaling pathways are outlined.
  • Recent advancements in (P)RR detection and therapeutic strategies are discussed.

Conclusions:

  • (P)RR in tumor tissues and body fluids shows promise as a biomarker for cancer diagnosis and prognosis.
  • (P)RR represents a potential therapeutic target for various cancers.
  • Further research and clinical application of (P)RR are anticipated.
Keywords:
(Pro) renin receptorBiomarkerCancerCancer targeted therapyRASWnt/β-catenin signaling pathway

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