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Updated: Dec 26, 2025
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A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
Published on: June 2, 2015
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Central vein sign for multiple sclerosis: A systematic review and meta-analysis
A Bhandari1, H Xiang2, J Lechner-Scott3
1Department of Anatomy, College of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia; Townsville University Hospital, Townsville, Queensland, Australia.
Clinical Radiology
|March 8, 2020
Summary
The central vein sign (CVS) is a valuable diagnostic marker for multiple sclerosis (MS). A meta-analysis suggests 45% of MS lesions should show the CVS for accurate diagnosis.
Area of Science:
- Neurology
- Radiology
- Medical Imaging
Background:
- Multiple sclerosis (MS) diagnosis relies on identifying characteristic lesions.
- The central vein sign (CVS) is a potential imaging biomarker for MS.
- Distinguishing MS from mimics is crucial for appropriate patient management.
Purpose of the Study:
- To systematically review the diagnostic value of the CVS in MS.
- To meta-analyze the proportion of lesions with CVS needed to differentiate MS from non-MS conditions.
Main Methods:
- A literature review and proportion meta-analysis were conducted.
- Studies with 100% diagnostic accuracy for CVS thresholds were included.
- The discriminative value of CVS was compared against MS mimics.
Main Results:
- The CVS is viable at 3 T and 1.5 T, with manual counting outperforming automated methods.
- Five studies contributed to the meta-analysis.
- A proportion of 46.4% (95% CI: 40.3%-52.6%) of MS lesions exhibiting the CVS was identified, with minimal heterogeneity.
Conclusions:
- The CVS is a clinically relevant and viable sign for MS diagnosis.
- Further research is needed to integrate the CVS into diagnostic criteria.
- Automated methods for CVS detection will enhance diagnostic efficiency and accuracy.
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