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Association between genetic variants in genes encoding Argonaute proteins and cancer risk: A meta-analysis

Zorana Dobrijević1, Suzana Matijašević2, Dušanka Savić-Pavićević2

  • 1Department for Metabolism, Institute for the Application of Nuclear Energy (INEP), University of Belgrade, Belgrade, Serbia.

Pathology, Research and Practice
|March 8, 2020
PubMed

Insights

Genetic variants in AGO1, specifically rs636832 and rs595961, are linked to increased cancer risk, particularly for solid tumors and lung cancer. Further research is needed for AGO2 variants.

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • Small RNA regulatory mechanisms are implicated in cancer development.
  • Genes encoding Argonaute (Ago) proteins are investigated for their role in cancer susceptibility.
  • Previous association study data on Ago protein variants and cancer risk has not been comprehensively meta-analyzed.

Purpose of the Study:

  • To conduct a meta-analysis of eligible studies to evaluate the association between Ago protein gene variants and overall cancer risk.
  • To investigate the potential effect of specific Ago1 and Ago2 genetic variants on susceptibility to various cancer types.

Main Methods:

  • A systematic literature search was performed using the PubMed database.
  • Quantitative data synthesis was conducted using OpenMeta-analyst and MetaGenyo software.
  • Multiple genetic models of association were tested for selected Ago gene variants.

Main Results:

  • The AGO1 genetic variant rs636832 showed a significant association with overall cancer risk under an overdominant model (P=0.030; OR=0.865).
  • This variant (rs636832) was also significantly associated with solid tumors and lung cancer susceptibility.
  • Another AGO1 variant, rs595961, showed similar associations in Asian cohorts, while the AGO2 variant rs4961280 did not yield statistically significant results.

Conclusions:

  • Genetic variants rs636832 and rs595961 within the AGO1 gene may be susceptibility variants for specific cancers, including lung cancer.
  • The association of the AGO2 variant rs4961280 with malignant diseases was not established in this meta-analysis.
  • These findings highlight the potential role of AGO1 variants in cancer predisposition.
Keywords:
AGO1AGO2ArgonauteCancerPolymorphismmicroRNA

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