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Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine
Published on: July 7, 2016
Improved Myocardial Function With Coronary Sinus Reducer in a Patient With Refractory Angina and Heart Failure With
Guglielmo Gallone1, Anna Palmisano2, Luca Baldetti3
1Division of Cardiology, "Città della Salute e della Scienza" Hospital, University of Turin, Turin, Italy.
Abstract:
The coronary sinus Reducer represents a novel therapeutic option with established safety and clinical benefit in the treatment of patients with refractory angina, possibly achieved by enhancing perfusion of myocardial ischemic territories. We report the first case providing insight on how improved perfusion might translate into improved myocardial function as assessed by cardiac magnetic resonance strain imaging, thus suggesting a physiological rationale to test coronary sinus Reducer in the setting of ischemic cardiomyopathy with reduced ejection fraction and adverse remodelling.
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