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Related Experiment Videos

[New analgesically-active N'-acylated phenylpiperazines].

G Oepen1, A Bork, V Jakovlev

  • 1Forschung der Asta Pharma AG, Frankfurt/Main.

Arzneimittel-Forschung
|November 1, 1988
PubMed
Summary
This summary is machine-generated.

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Researchers synthesized novel analgesic compounds, N'-acylated phenylpiperazines. Compound D 16 120 demonstrated potent non-opiate antinociceptive effects with a favorable safety profile.

Area of Science:

  • Medicinal Chemistry
  • Pharmacology

Context:

  • Development of novel analgesic agents.
  • Need for non-opiate pain relief options.

Purpose:

  • To synthesize and evaluate new N acylated phenylpiperazine derivatives for analgesic activity.
  • To characterize the pharmacodynamic properties and safety of novel compounds.

Summary:

  • Synthesis of N acylated phenylpiperazines, including 1-(3-Cyclohexyl-1-oxo-propyl)-4-(2-ethoxyphenyl)-piperazine (D 16 120).
  • D 16 120 exhibits significant non-opiate antinociceptive activity.
  • Compound D 16 120 shows a wide therapeutic margin, indicating low toxicity and minimal side effects.

Impact:

  • Identifies a promising new class of non-opiate analgesics.

Related Experiment Videos

  • Provides a lead compound (D 16 120) for further preclinical and clinical development.
  • Contributes to the understanding of structure-activity relationships in analgesic phenylpiperazines.