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Updated: Dec 26, 2025

The Application of Point-of-Care Ultrasonography (POCUS) in the Management of Acute Respiratory Distress Syndrome (ARDS) in the Intensive Care Unit
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Determining Optimal Outcome Measures in a Trial Investigating No Routine Gastric Residual Volume Measurement in

Lyvonne N Tume1, Barbara Arch2, Kerry Woolfall3

  • 1University of Salford, Manchester, UK.

JPEN. Journal of Parenteral and Enteral Nutrition
|March 8, 2020
PubMed

Insights

Selecting relevant outcomes is crucial for pediatric critical care trials. This study identified 12 key outcome measures for trials evaluating no routine gastric residual volume (GRV) measurement, incorporating parent and clinician input.

Area of Science:

  • Pediatric critical care research
  • Clinical trial methodology
  • Outcome measure development

Background:

  • Clinical trial outcomes must be relevant to patients and parents for effective implementation.
  • Lack of relevant outcomes can hinder the adoption of trial evidence into practice.
  • Determining optimal outcome measures is essential for high-quality research in pediatric intensive care.

Purpose of the Study:

  • To identify and establish optimal outcome measures for a clinical trial.
  • The trial focuses on the practice of withholding routine gastric residual volume (GRV) measurement in critically ill children.
  • Incorporate perspectives of parents and clinicians in outcome selection.

Main Methods:

  • A mixed-methods approach was employed.
  • Included a focused literature review, parent and clinician interviews, a modified Delphi method (2 rounds), and a stakeholder consensus meeting.
  • Multistage process involving iterative rating and voting by participants.

Main Results:

  • An initial 13 outcomes were identified from the literature review.
  • Parents and clinicians proposed additional outcomes, leading to a total of 22 considered.
  • A final set of 12 outcome measures was selected through consensus, including time to energy targets, VAP, vomiting, and feed intolerance markers.

Conclusions:

  • Identified 12 essential outcome measures for a trial on omitting routine gastric residual volume measurements.
  • The selection process prioritized input from parents and clinicians.
  • These outcomes will enhance the relevance and applicability of trial findings in pediatric critical care.
Abstract

Keywords:
childenteral feedingintensive carenutritionpediatrictrials

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