[Premature aging in sleep apnea comorbid obesity persons.]

Area of Science:

• Cardiovascular Medicine
• Neurology
• Gerontology

Background:

• Obstructive sleep apnea (OSA) and obesity are prevalent conditions often co-occurring.
• These conditions are increasingly linked to accelerated aging and cardiovascular complications.
• Cerebral hemodynamics plays a crucial role in maintaining brain health.

Purpose of the Study:

• To investigate the association between pathological changes in cerebral hemodynamics and premature aging in patients with OSA and comorbid obesity.
• To identify specific hemodynamic markers predictive of accelerated aging in this patient population.

Main Methods:

• Assessment of common carotid artery wall remodeling (concentric-eccentric).
• Evaluation of cerebral angiopathy (hyperconstrictor variant).
• Analysis of cerebral blood flow autoregulation compensatory mechanisms and hemodynamic reserve.

Main Results:

• Patients with OSA and comorbid obesity exhibited significantly accelerated biological aging compared to chronological age.
• Cerebral hemodynamic indicators, including intima-media thickness and microvasculature reactivity, were significant predictors of premature aging.
• The cerebral blood flow index emerged as an additional marker for early aging in comorbid individuals.

Conclusions:

• Patients with OSA and obesity experience accelerated aging rates.
• Cerebral hemodynamic parameters serve as valuable markers for assessing premature aging in these patients.
• Targeting hemodynamic dysregulation may be crucial for mitigating accelerated aging in OSA and obesity.