Surgery and Proton Beam Therapy for Tracheal Synovial Sarcoma

Area of Science:

• Oncology
• Surgical Oncology
• Radiation Oncology

Background:

• Synovial sarcoma (SS) is a rare malignancy with a poor prognosis.
• Tracheal synovial sarcoma is exceptionally rare, with limited documented cases.

Observation:

• A 19-year-old male presented with a soft tissue density mass in the lower trachea.
• Imaging studies identified the tracheal mass.

Findings:

• The patient underwent en bloc tracheal segmental resection and postoperative proton beam therapy.
• Diagnosis was confirmed by the SS18-SSX gene rearrangement, characteristic of synovial sarcoma.
• The patient remained disease-free for 18 months post-treatment.

Implications:

• This case highlights the successful management of a rare tracheal synovial sarcoma.
• Combined surgical resection and proton therapy represent a viable treatment strategy for tracheal SS.
• Further research into optimal treatment protocols for rare tracheal tumors is warranted.