Related Experiment Video
Updated: Dec 26, 2025
07:56
Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
Published on: January 29, 2018
18.1K
The accurate relationship between spine bone density and bone marrow in humans
Xiaoguang Cheng1, Kai Li1, Yong Zhang1
1Department of Radiology, Beijing Jishuitan Hospital, Beijing 100035, China.
Bone
|March 8, 2020
Summary
Bone marrow adipose tissue (BMAT) affects bone density measurements. Correcting for BMAT reveals its inverse relationship with volumetric bone mineral density (vBMD) in the lumbar spine.
Area of Science:
- Bone biology and imaging
- Osteoporosis research
- Medical physics
Background:
- Quantitative CT (QCT) measurements of lumbar spine trabecular volumetric bone mineral density (vBMD) are affected by bone marrow adipose tissue (BMAT).
- Differences in BMAT can decrease the accuracy of vBMD measurements.
Purpose of the Study:
- To correct vBMD measurements for variations in marrow composition.
- To investigate the true relationship between vBMD and BMAT.
Main Methods:
- A cross-sectional study involving 400 healthy Chinese adults (233 women, 167 men) aged 21-82 years.
- vBMD and BMAT were measured using QCT and MRI of the L2-L4 vertebrae.
- Linear regression analysis was used to assess BMAT, age, and corrected vBMD.
Main Results:
- BMAT increased with age in both sexes, with a faster rate in women.
- After BMAT correction, statistically significant changes in the age-related slope of vBMD were observed in both sexes.
- vBMD decreased linearly with increasing BMAT in both men and women.
Conclusions:
- The developed approach accurately corrects vBMD measurements for BMAT.
- This method provides a new tool for understanding the interaction between bone and marrow adipose tissue.
More Related Videos
09:07A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts
Published on: December 16, 2022
3.7K
10:39Longitudinal Evaluation of Mouse Hind Limb Bone Loss After Spinal Cord Injury using Novel, in vivo, Methodology
Published on: December 7, 2011
15.5K
Related Concept Videos
01:29Bone Disorders
5.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.0K
01:09Spongy Bone
7.3K
All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
7.3K
01:18The Bone Matrix
5.3K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
5.3K
01:23Bone as Supporting Connective Tissue
6.2K
Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
6.2K
01:27Compact Bone
15.7K
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
15.7K
01:22The Functions of the Skeletal System
5.6K
The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
5.6K