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Do asymptomatic clots in children matter?

Sophie Jones1, Paul Monagle2, Fiona Newall3

  • 1Haematology Research Group, Murdoch Children's Research Institute, Melbourne, Australia; Department of Clinical Haematology, The Royal Children's Hospital, Melbourne, Australia; Department of Nursing, The University of Melbourne, Australia.

Thrombosis Research
|March 8, 2020
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Summary
This summary is machine-generated.

Asymptomatic venous thrombosis in children, often linked to central venous catheters, requires careful consideration for treatment. Current evidence is insufficient to definitively guide management, necessitating further research.

Keywords:
AsymptomaticCentral venous catheterChildrenVenous thromboembolism

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Area of Science:

  • Pediatric Medicine
  • Hematology
  • Vascular Medicine

Background:

  • Asymptomatic venous thrombosis is a frequent complication in hospitalized children.
  • Current guidelines advocate for treating all asymptomatic venous thrombosis, regardless of incidental diagnosis or resolved risk factors.
  • The necessity and risks of treating asymptomatic thrombosis in children remain unclear.

Purpose of the Study:

  • To review the current evidence on asymptomatic thrombosis in pediatric patients.
  • To evaluate the necessity of screening for asymptomatic thrombosis.
  • To assess the risk-benefit ratio of treatment and potential long-term morbidity.

Main Methods:

  • Literature review of existing evidence on pediatric asymptomatic thrombosis.
  • Analysis of data concerning incidence, characteristics, and outcomes.
  • Discussion of risk factors, including central venous catheters (CVCs).

Main Results:

  • Asymptomatic thrombosis is common in hospitalized children, particularly those with cancer, neonates, and critically ill children.
  • Central venous catheters (CVCs) are a frequent association.
  • Data on incidence and outcomes are often imprecise, lacking distinction from symptomatic thrombosis.

Conclusions:

  • The clinical significance of asymptomatic venous thromboembolism (VTE) in children requires further investigation.
  • Prospective studies with extended follow-up are essential to determine optimal management strategies.
  • The risk-benefit balance of anticoagulation treatment needs careful evaluation.