Related Experiment Video

Updated: Dec 26, 2025

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
06:21

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Published on: May 10, 2024

1.1K

Pharmacogenomics for the efficacy of platinum-based chemotherapy: Old drugs, new integrated perspective

Chen-Xue Mao1, Min Li2, Wei Zhang3

  • 1Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, PR China; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, PR China; Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Changsha 410078, PR China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|March 8, 2020
PubMed

Insights

Identifying effective platinum-based chemotherapy requires new biomarkers. This review explores multifactorial markers, including genetics and gut microbes, to predict patient response and overcome platinum resistance.

Area of Science:

  • Oncology and Pharmacology
  • Genomics and Microbiomics

Background:

  • Platinum-based chemotherapy is a primary cancer treatment.
  • Individual patient response varies significantly.
  • Current clinical practice lacks biomarkers for predicting platinum drug efficacy and stratifying patients.

Purpose of the Study:

  • To critically review potential pharmacogenomic biomarkers for platinum drug efficacy.
  • To provide a comprehensive, time-varying perspective integrating multiple markers.
  • To address the need for biomarkers in personalized cancer therapy.

Main Methods:

  • Literature review of high-throughput screening techniques.
  • Systems biology approaches to understand platinum resistance.
  • Analysis of multifactorial determinants of drug response.

Main Results:

  • Platinum resistance is a complex, dynamic process influenced by genetic background, tumor evolution, and gut microbiota.
  • Multiple pharmacogenomic biomarkers show potential for predicting treatment outcomes.
  • Integration of diverse markers offers a more holistic view of drug response.

Conclusions:

  • Pharmacogenomic biomarkers are crucial for optimizing platinum-based chemotherapy.
  • A multifactorial and dynamic approach is needed to predict treatment efficacy.
  • Future research should focus on integrating diverse markers for clinical application.
Keywords:
BiomarkerEfficacyPharmacogenomicsPlatinumResistance

More Related Videos

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo09:19

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

9.0K
Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents07:20

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

14.3K

Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.8K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.6K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K
Nonlinear Pharmacokinetics: Role of Transporters01:27

Nonlinear Pharmacokinetics: Role of Transporters

A drug's nonlinear kinetics can be influenced by a diverse range of transporter proteins that serve as crucial players in drug distribution. These transporters, found within cells, can enhance or reduce local drug concentrations by facilitating the influx or efflux of drugs. For instance, the expression of xenobiotic transporters can be influenced by factors such as age and gender, potentially impacting the linearity of drug response.
Polymorphisms occurring in drug transporters can alter...
226