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Biomarkers in atrial fibrillation and heart failure with non-reduced ejection fraction: Diagnostic application and

Ana Merino-Merino1, Ruth Saez-Maleta2, Ricardo Salgado-Aranda1

  • 1Cardiology Department, Universitary Hospital of Burgos, Burgos, Spain.

Heart & Lung : the Journal of Critical Care
|March 9, 2020
PubMed

Insights

N-terminal pro-B-type natriuretic peptide (NT-proBNP) best identifies heart failure with non-reduced ejection fraction (HFmrEF) in atrial fibrillation (AF) patients. Troponin distinguishes HFmrEF from HFpEF.

Area of Science:

  • Cardiology
  • Biomarker Research
  • Heart Failure Diagnostics

Background:

  • Atrial fibrillation (AF) and heart failure (HF) with non-reduced left ventricle ejection fraction (LVEF) share diagnostic challenges.
  • This study investigates biomarker differences in symptomatic AF patients with and without HF.
  • Specific focus on differentiating HF with mid-range EF (HFmrEF) from HF with preserved EF (HFpEF).

Purpose of the Study:

  • To analyze biomarker variations between AF patients with and without HF, specifically focusing on non-reduced LVEF.
  • To compare biomarker profiles differentiating HFmrEF from HFpEF in symptomatic AF patients.

Main Methods:

  • Included 115 patients with symptomatic persistent AF.
  • Measured seven biomarkers: NT-proBNP, hsTNT, galectin-3, ST2, fibrinogen, urate, and C-reactive protein.

Main Results:

  • Patients with non-reduced LVEF HF showed significantly higher NT-proBNP levels.
  • NT-proBNP was the sole independent predictor for non-reduced LVEF HF.
  • Troponin was the only independent predictor for HFmrEF.

Conclusions:

  • NT-proBNP demonstrated superior diagnostic accuracy for non-reduced LVEF HF, with higher cut-off values than previously reported.
  • Troponin proved to be the most accurate biomarker for differentiating HFmrEF from HFpEF.
Abstract

Keywords:
Atrial fibrillationBiomarkersDiastolic heart failureGalectin 3Nt proBNP

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