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Updated: Dec 26, 2025

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Psoriasis Induced by Biological Therapy
Lydia Montolio Chiva1, Àngels Martínez Ferrer1, Almudena Mateu Puchades2
1Servicio de Reumatología, Hospital Universitario Doctor Peset, Valencia, España.
Objective:
To describe a multicentre case series of new onset or worsening of psoriasis in patients treated with biological drugs.
Material And Methods:
Descriptive study. We reviewed the clinical history of patients with chronic inflammatory disease (CID) treated with biological drugs, who developed new onset or worsening of psoriasis during the follow-up period.
Results:
Twenty-six cases of paradoxical psoriasis (PP) were recorded. Ninety-three percent of the patients were treated with anti-TNFα and adalimumab was responsible for 50% of the cases. Only 5 patients had a personal history of psoriasis. The biological drug was discontinued in 13 patients. Lesion recurrence was more frequent when another anti-TNFα was reintroduced.
Conclusions:
The PP is a reversible adverse effect that can be observed in patients exposed to biological drugs, mainly anti-TNFα.
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