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In-hospital mortality in patients with systemic lupus erythematosus: a study from Jordan 2002-2017
Marwan H Adwan1, Ula Qasem1, Khader N Mustafa2
1Department of Internal Medicine, Division of Rheumatology, The University of Jordan, Jordan University Hospital, Queen Rania Street, PO Box 13046, Amman, 11942, Jordan.
Rheumatology International
|March 9, 2020
Summary
Hospitalized patients with systemic lupus erythematosus (SLE) faced a 14% in-hospital fatality rate over 15 years. Infections and active SLE complications were primary causes of death, particularly in younger patients with shorter disease durations.
Area of Science:
- Rheumatology
- Internal Medicine
- Public Health
Background:
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with significant morbidity and mortality.
- Understanding mortality patterns in hospitalized SLE patients is crucial for improving clinical management and outcomes.
Purpose of the Study:
- To investigate the mortality rates and causes among patients hospitalized with SLE.
- To identify demographic and clinical factors associated with mortality in this population.
Main Methods:
- Retrospective cross-sectional study of 283 SLE patients hospitalized at Jordan University Hospital between 2002 and 2017.
- Analysis of in-hospital case fatality, causes of death, and patient demographics.
Main Results:
- The in-hospital case fatality rate was 14% over the 15-year study period.
- Infections (42.5%) and SLE-related complications (40%) were the leading causes of mortality.
- Infection-related deaths occurred at a younger age and shorter disease duration compared to SLE-related deaths.
Conclusions:
- Infections and active SLE complications are major contributors to mortality in hospitalized SLE patients.
- Pulmonary disease is a significant cause of SLE-related mortality, suggesting a potential shift in mortality trends.
- Early identification and management of infections and SLE flares are critical for reducing mortality in hospitalized SLE patients.
