Related Experiment Video

Updated: Dec 26, 2025

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound
06:08

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound

Published on: March 21, 2025

960

Age-related and zonal anatomical microstructure features of normal prostatic tissues: a preliminary study with

Xiangyu Wang1, Yuli Wang1, Liang Zeng1

  • 1Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen, 518035, China.

Abdominal Radiology (New York)
|March 9, 2020
PubMed
Abstract

Insights

Vascular, extracellular and restricted diffusion for cytometry in tumors (VERDICT) parameters differ across prostate regions and correlate with age. These findings align with prostate histology, offering insights into normal tissue variations.

Area of Science:

  • Radiology and Imaging
  • Prostate Cancer Research
  • Biomedical Engineering

Background:

  • Understanding normal prostate tissue characteristics is crucial for accurate disease detection.
  • Vascular, extracellular and restricted diffusion for cytometry in tumors (VERDICT) is an advanced imaging technique that provides insights into tissue microstructure.
  • Previous studies have not fully elucidated regional and age-related variations in VERDICT parameters within normal prostate tissue.

Purpose of the Study:

  • To investigate the differences in VERDICT parameters (intracellular volume fraction [fIC], extracellular-extravascular space fraction [fEES], and vascular fraction [fVASC]) in normal prostate tissues across different anatomical regions (peripheral zone [PZ], central gland [CG], anterior fibromuscular stroma [AS]).
  • To explore the correlation between age and these VERDICT parameters in different prostate regions.

Main Methods:

  • 31 male volunteers underwent MRI scans.
  • VERDICT model parameters (fIC, fEES, fVASC) were calculated for the whole prostate and specific regions (PZ, CG, AS).
  • Statistical analyses, including two-way ANOVA and Spearman's correlation, were used to assess differences among regions and age groups and to evaluate age-related changes.

Main Results:

  • Significant differences in VERDICT parameters were observed among prostate regions (P < 0.05).
  • In the PZ, age negatively correlated with fIC (r = -0.66) and positively with fEES (r = 0.69).
  • In the CG, age positively correlated with fEES (r = 0.56), while no significant correlations were found in the AS.

Conclusions:

  • VERDICT parameters exhibit regional variability within the normal prostate.
  • Age is a significant factor influencing VERDICT parameters, particularly fIC and fEES in the PZ and fEES in the CG.
  • These findings support histological understanding and may aid in the interpretation of prostate MRI.
Keywords:
AgeNormal prostatic tissuesRegionVERDICT MRI

More Related Videos

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking07:34

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

Published on: November 17, 2023

1.1K
Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly12:50

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Published on: April 14, 2014

40.7K

Related Concept Videos

Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
192
Imaging Studies I: Kidney, Ureter, and Bladder Studies01:28

Imaging Studies I: Kidney, Ureter, and Bladder Studies

Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
193
Imaging Studies VI: Voiding Cystourethrography and Cystography01:22

Imaging Studies VI: Voiding Cystourethrography and Cystography

Voiding Cystourethrography (VCUG) and Cystography are specialized radiographic procedures used to examine the structure and function of the bladder and urethra.Voiding Cystourethrography (VCUG)A Voiding Cystourethrogram (VCUG) is a diagnostic imaging procedure that assesses the anatomy and function of the lower urinary tract. It focuses on the bladder, bladder neck, and urethra, helping detect abnormalities such as vesicoureteral reflux (VUR)—the backward or reverse flow of urine into the...
879
Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
713