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Updated: Dec 26, 2025

Methods for Acute and Subacute Murine Hindlimb Ischemia
Published on: June 21, 2016
Acute Limb Ischemia Interventions
1Department of Medicine, Cardiovascular Section, University of Oklahoma Health Sciences Center, 800 Stanton L. Young Boulevard, AAT 5400, Oklahoma City, OK 73131, USA.
Abstract:
Acute limb ischemia (ALI) is a sudden decrease in limb perfusion that threatens limb viability. Using the Rutherford classification, limbs can be categorized as threatened but viable, or irreversibly damaged, which aids clinicians in selecting appropriate therapy. Treatment options for threatened limbs include catheter-directed thrombolysis, percutaneous mechanical thrombectomy, and surgical revascularization. Potential complications from ALI and treatment include ischemia-reperfusion injury, compartment syndrome, systemic inflammatory response syndrome, multiple organ dysfunction syndrome, hyperkalemia, and bleeding.
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