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Expert recommendations for the management of fecal incontinence in systemic sclerosis: A report from the World Scleroderma Foundation (WSF) Gastrointestinal "Ad hoc committee".

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Updated: Dec 26, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Scleroderma mimics - Clinical features and management.

Catherine H Orteu1, Voon H Ong2, Christopher P Denton2

  • 1Department of Dermatology, Royal Free London NHS Foundation Trust, Pond Street, London NW3 2QG, UK.

Best Practice & Research. Clinical Rheumatology
|March 10, 2020
PubMed
Summary
This summary is machine-generated.

Systemic sclerosis, a severe rheumatic disease, shares symptoms with other skin-sclerosis conditions. Accurate diagnosis is crucial for proper management and monitoring of potential complications.

Keywords:
FasciitisGraft versus host diseaseMorphoeaNephrogenic systemic fibrosisRaynaud's phenomenonSclerodermaScleromyxoedemaSystemic sclerosis

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Area of Science:

  • Rheumatology
  • Dermatology
  • Immunology

Background:

  • Systemic sclerosis is a severe, immune-mediated rheumatic disease with significant clinical impact and mortality.
  • Differential diagnosis of systemic sclerosis includes other sclerosing skin diseases requiring specialist care.
  • Long-term management must consider associated complications and therapy duration for various fibrotic conditions.

Purpose of the Study:

  • To review the clinical features of conditions mimicking systemic sclerosis.
  • To differentiate systemic sclerosis from localized scleroderma (morphea) and other fibrotic skin diseases.
  • To aid in specialist investigation and management of sclerosing skin disorders.

Main Methods:

  • Review of clinical features of systemic sclerosis mimics.
  • Comparison of clinical presentations of scleroderma variants and other fibrosing conditions.
  • Literature synthesis on differential diagnosis and management strategies.

Main Results:

  • Identified key clinical features distinguishing systemic sclerosis from its mimics.
  • Highlighted the importance of recognizing localized scleroderma (morphea) as a differential diagnosis.
  • Emphasized the need for tailored follow-up and therapy based on specific fibrotic conditions.

Conclusions:

  • Accurate differentiation of systemic sclerosis from other sclerosing skin diseases is essential for appropriate patient management.
  • Recognizing mimics like morphea ensures timely specialist intervention and reduces diagnostic delays.
  • Understanding the spectrum of fibrotic skin conditions informs long-term care and complication monitoring.