Related Experiment Video
Updated: Dec 26, 2025
Development of an In Vitro Ocular Platform to Test Contact Lenses
Published on: April 6, 2016
Introducing a novel in vivo method to access visual performance during dewetting process of contact lens surface
Oliver Kolbe1, Felix Zimmermann2, Sebastian Marx2
1Jenvis Research c/o Ernst-Abbe University of Applied Sciences Jena, Carl-Zeiss-Promenade 2, 07745, Jena, Germany; Faculty of SciTec, Department of Optometry and Vision Sciences, Ernst-Abbe University of Applied Sciences Jena, Carl-Zeiss-Promenade 2, 07745, Jena, Germany.
Purpose:
To introduce a novel in vivo method (Visual Acuity Dry Up; VADU) for testing the visual performance during the dewetting of the pre-lens tear film on a contact lens (CL).
Methods:
Thirty-nine subjects were fitted with daily disposable CL (Nelfilcon A). Visual performance and dewetting characteristics of the pre-lens tear film were simultaneously assessed using a modified multifunctional topographer (Keratograph 5 M, OCULUS Optikgeräte GmbH, Wetzlar, GERMANY) and the Non-Invasive Keratograph Dry-Up Time (NIKDUT) method. Measures were taken after five minutes and eight hours of CL wear and included the Visual Acuity Dry-Up Time (VADUT; time between last blink and visual breakdown) and the Visual Acuity Dry-Up Area (VADUA; dewetted CL area at visual breakdown) at one (VA+0.1logMAR), two (VA+0.2logMAR) and three (VA+0.3logMAR) log units below maximal visual acuity (VA).
Results:
Participants lost one, two or three log units of VA after 13.1 ± 17.4 s, 20.83 ± 21.81, 34.67 ± 29.11 (VADUT), corresponding to a dewetted CL area of 4.82 ± 6.64 mm², 9.5 ± 8.26 and 13.0 ± 8.68 (VADUA), respectively. Differences in VADUT und VADUA for all visual requirements were significant (all p < 0.05). VADUT and VADUA did not vary with CL wear duration (all p > 0.05). A median VA loss of one log unit occurred five seconds after the first dewetting.
Conclusions:
The novel VADU method can be used to analyze the role of the tear film stability on the visual performance during CL wear. Hereby, visual loss is quantified based on the threshold definition of the psychometric function.
