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HOX genes function in Breast Cancer development.

Simone Aparecida de Bessa Garcia1, Mafalda Araújo1, Tiago Pereira1

  • 1IBMC- Institute for Molecular and Cell Biology, I3S- Institute for Innovation and Health Research, Universidade do Porto, Portugal.

Biochimica Et Biophysica Acta. Reviews on Cancer
|March 10, 2020
PubMed
Summary

HOX genes, particularly HOXB, are implicated in breast cancer development and aggressiveness. Deregulation of these HOX genes presents new therapeutic targets for overcoming tamoxifen resistance in breast cancer treatment.

Keywords:
Breast CancerHOX clustersHOXB genesMammary glandsMolecular subtypesTherapeutic targetsTranscription factors

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Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Breast cancer is a leading cause of cancer-related mortality in women.
  • Mammary gland development is regulated by hormones and transcription factors, including HOX genes.
  • HOX gene deregulation is linked to breast cancer development and progression.

Purpose of the Study:

  • To review the role of HOX genes in breast cancer.
  • To focus on the HOXB cluster's involvement in breast cancer aggressiveness and tamoxifen resistance.
  • To discuss HOXB genes as potential therapeutic targets.

Main Methods:

  • Literature review of HOX gene function in breast cancer.
  • Analysis of HOXB gene expression alterations in breast cancer.
  • Discussion of HOXB genes' impact on prognosis and therapeutic resistance.

Main Results:

  • 8 out of 10 HOXB genes show altered expression in breast cancer.
  • HOXB gene deregulation correlates with increased breast cancer aggressiveness.
  • Altered HOXB gene expression is associated with resistance to hormone therapy, including tamoxifen.

Conclusions:

  • HOX genes, especially HOXB, are critical in breast cancer development and progression.
  • HOXB gene deregulation significantly impacts patient prognosis and treatment outcomes.
  • Targeting HOXB genes offers a promising strategy to overcome tamoxifen resistance in breast cancer therapy.