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Progesterone challenge test in postmenopausal women with pathological endometrium
I G Gorodeski1, A Geier, B Lunenfeld
1Department of Obstetrics and Gynecology B, Meir Hospital, Sapir Medical Center, Kfar Saba, Israel.
Cancer Investigation
|January 1, 1988
Summary
Progesterone administration alters progesterone receptor distribution in human endometria. Nuclear progesterone receptor (RPN) levels increase while cytosolic progesterone receptor (RPC) levels decrease, with a more pronounced shift in normal tissues.
Area of Science:
- Endocrinology
- Gynecology
- Molecular Biology
Background:
- Progesterone is a key hormone regulating the endometrium.
- Understanding progesterone receptor (RP) distribution is crucial for endometrial physiology and pathology.
Purpose of the Study:
- To investigate the effect of acute progesterone administration on cytosolic (RPC) and nuclear (RPN) progesterone receptor levels in normal and pathological human endometria.
Main Methods:
- Measurement of RPC and RPN levels in endometrial tissue samples.
- Comparison between subjects receiving a single progesterone dose and untreated controls.
- Analysis of receptor distribution in various endometrial conditions.
Main Results:
- Progesterone injection led to increased RPN and decreased RPC levels in normal endometria.
- Similar but less pronounced changes in RP distribution were observed in pathological endometria.
- Estrogen-primed postmenopausal endometria also showed altered RP distribution.
Conclusions:
- Acute progesterone exposure significantly shifts progesterone receptor localization towards the nucleus in human endometria.
- The magnitude of this shift differs between normal and pathological endometrial tissues.