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Mean and variability of annual haemoglobin A1c are associated with high-risk peripheral artery disease

I-Te Lee1,2,3,4

  • 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung City.

Diabetes & Vascular Disease Research
|March 10, 2020
PubMed

Insights

High glucose variability, measured by haemoglobin A1c fluctuations, increases peripheral artery disease risk in type 2 diabetes patients. This finding highlights the importance of stable blood sugar control for cardiovascular health.

Area of Science:

  • Endocrinology and Metabolism
  • Cardiovascular Research
  • Diabetes Management

Background:

  • Glucose variability is a known predictor of cardiovascular events and mortality.
  • The link between peripheral artery disease (PAD) and glucose variability requires further investigation.

Purpose of the Study:

  • To assess the association between the standard deviation of annual haemoglobin A1c and the risk of peripheral artery disease in type 2 diabetes patients.

Main Methods:

  • Retrospective analysis of 4144 type 2 diabetes patients.
  • Evaluation of ankle-brachial index (ABI) and percentage of mean arterial pressure at the ankle.
  • Calculation of the standard deviation of annual haemoglobin A1c levels.

Main Results:

  • Higher standard deviation of annual haemoglobin A1c was observed in patients with ABI ≤0.90 and those with percentage of mean arterial pressure ≥45%.
  • Elevated haemoglobin A1c variability is significantly associated with high-risk peripheral artery disease (OR=1.306, p=0.014).

Conclusions:

  • Fluctuations in haemoglobin A1c levels indicate an increased risk of peripheral artery disease in type 2 diabetes.
  • Maintaining stable glucose control is crucial for reducing PAD risk in diabetic patients.
Abstract

Keywords:
Ankle-brachial indexhaemoglobin A1cpercentage of the mean arterial pressureperipheral artery diseasetype 2 diabetesvariability

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