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Hemophagocytic Lymphohistiocytosis Related to Tuberculosis Disease

Seher Erdoğan¹, Deniz Çakır², Tuğçe Bozkurt³

¹Department of Pediatric Critical Care, University of Health Sciences, Ümraniye Training and Research Hospital, Istanbul, Turkey.

Indian Journal of Critical Care Medicine : Peer-Reviewed, Official Publication of Indian Society of Critical Care Medicine

|March 10, 2020

Abstract:

Hemophagocytic lymphohistiocytosis (HLH) is a rare, albeit potentially fatal, condition in which fever, hepatosplenomegaly, and cytopenia predominate the clinical picture. Although it may be primary, it may also develop secondary to various etiologies. Herein, we aimed to report a patient who was diagnosed with pulmonary tuberculosis, developed fever and cytopenia during follow-up, and received immunomodulatory therapy together with antituberculosis therapy for the diagnosis of HLH. Sequencing of PRF1 showed heterozygous mutation. Although primary HLH has been detected in infants and children, genetic mutation of genes should be considered a differential diagnosis of HLH even in the adolescent.

How To Cite This Article:

Erdoğan S, Çakır D, Bozkurt T, Karakayalı B, Kalın S, Koç B, et al. Hemophagocytic Lymphohistiocytosis Related to Tuberculosis Disease. Indian J Crit Care Med 2020;24(1):63-65.

Keywords:

Hemophagocytic lymphohistiocytosis Therapeutic plasma exchange Tuberculosis

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