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Inflammation01:38

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Updated: Dec 26, 2025

Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
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Increased Mast Cell Counts and Degranulation in Microscopic Colitis.

Zhikai Chi1, Jing Xu1, Romil Saxena2

  • 1Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Gastroenterology Research and Practice
|March 10, 2020
PubMed
Summary
This summary is machine-generated.

Microscopic colitis (MC) involves increased mast cells and their activation, suggesting a role in the condition's development. This study analyzed mast cell counts and degranulation in MC patients compared to controls.

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Area of Science:

  • Gastroenterology
  • Immunology
  • Pathology

Background:

  • Microscopic colitis (MC) presents with chronic diarrhea and inflammation in colonic biopsies, despite normal colonoscopies.
  • MC subtypes include collagenous colitis (CC) and lymphocytic colitis (LC).
  • The exact pathogenesis of microscopic colitis remains largely unknown.

Purpose of the Study:

  • To investigate mast cell counts and activation status in patients with microscopic colitis.
  • To determine if mast cell degranulation is a feature of microscopic colitis.

Main Methods:

  • Analysis of 64 biopsy samples from microscopic colitis (CC or LC) patients and 20 control samples.
  • Immunohistochemistry was used to quantify mast cells and detect intracellular/extracellular tryptase.

Main Results:

  • Mast cell counts were significantly higher in the lamina propria of both CC and LC patients compared to controls.
  • Extracellular tryptase, indicating mast cell degranulation, was found in 41% of CC patients versus 10% of controls.
  • A similar trend of increased extracellular tryptase was observed in LC patients (data not fully shown in abstract).

Conclusions:

  • Microscopic colitis is associated with an increased number of mast cells.
  • Evidence of mast cell degranulation suggests mast cell activation plays a role in the pathogenesis of microscopic colitis.