The Role of Oxidative Stress in Common Risk Factors and Mechanisms of Cardio-Cerebrovascular Ischemia and Depression

Area of Science:

• Public Health
• Cardiology
• Neurology
• Psychiatry

Background:

• Ischemic cardiovascular and cerebrovascular diseases (CVD) and depression pose significant public health challenges.
• Existing treatments lack breakthroughs, particularly for depression influenced by social factors.
• CVD and depression share common risk factors like obesity, diabetes, and hypertension.

Purpose of the Study:

• To review the relationship between ischemic CVD and depression.
• To describe shared risk factors and mechanisms.
• To propose oxidative stress (OS) as a mediator and highlight antioxidant potential.

Main Methods:

• Literature review summarizing existing research.
• Analysis of shared risk factors (obesity, diabetes, hypertension).
• Examination of common pathophysiological mechanisms (OS, inflammation, gut-brain axis).

Main Results:

• CVD and depression are correlated, sharing common risk factors and mechanisms.
• Oxidative stress (OS) is proposed as a key mediator in the crosstalk between CVD and depression.
• Inflammation, immune response, cell death pathways, and the microbiome-gut-brain axis are implicated.

Conclusions:

• Understanding shared mechanisms is crucial for developing integrated treatment strategies.
• Oxidative stress (OS) plays a pivotal role in linking ischemic CVD and depression.
• Antioxidants show promise for mitigating OS-related damage in both conditions.