Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Motility through Blebbing01:16

Cell Motility through Blebbing

2.3K
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
2.3K
Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

3.0K
Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
3.0K
The Role of Actin and Myosin in Non-muscle Cells01:10

The Role of Actin and Myosin in Non-muscle Cells

4.4K
Actin and myosin or actomyosin filaments also play a significant role in cells other than those involved in muscle contraction (which occurs within the sarcomere of muscle cells). The mechanism of non-muscle cell contractile bundles was first observed in Dictyostelium and Acanthamoeba. In non-muscle cells, two bundles are commonly found: stress fibers and actomyosin adherence belts. These contractile bundles are smaller and less organized than the ones found in muscle cells. They  are held...
4.4K
Smooth Muscle Contraction01:25

Smooth Muscle Contraction

6.9K
Smooth muscle contraction is a complex process vital for various bodily functions, from maintaining blood vessel tension to facilitating the movement of food through the digestive tract. Unlike striated muscles, smooth muscle contraction begins more slowly and lasts longer.
The onset of contraction is triggered by an increase in calcium ions within the sarcoplasm, similar to the process in striated muscle. However, smooth muscles have a relatively smaller reservoir of the sarcoplasmic...
6.9K
Mechanism of Lamellipodia Formation01:31

Mechanism of Lamellipodia Formation

3.4K
Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
3.4K
Actin and Myosin in Muscle Contraction01:16

Actin and Myosin in Muscle Contraction

19.7K
Actin and myosin are contractile proteins that form the sarcomere found in skeletal muscle tissues for regulating muscle contraction. Actin, a globular contractile protein, interacts with myosin for muscle contraction. The skeletal tissue appears striped or striated under a microscope due to the repeated arrangement of contractile proteins actin and myosin along the length of myofibrils. Dark A bands and light I bands repeat along myofibrils, and the alignment of myofibrils in the cell causes...
19.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rac1 and Nectin3 are essential for planar cell polarity-directed axon guidance in the peripheral auditory system.

Development (Cambridge, England)·2025
Same author

Inferring active and passive mechanical drivers of epithelial convergent extension.

bioRxiv : the preprint server for biology·2025
Same author

Rac1 and Nectin3 are essential for PCP-directed axon guidance in the peripheral auditory system.

bioRxiv : the preprint server for biology·2024
Same author

The primitive streak and cellular principles of building an amniote body through gastrulation.

Science (New York, N.Y.)·2021
Same author

Convergent extension in mammalian morphogenesis.

Seminars in cell & developmental biology·2019
Same journal

Cyber Military Operations under International Humanitarian Law: Interpreting the Concept of "Attack" and Challenges in Protecting Civilians.

F1000Research·2026
Same journal

Sentiment Analysis of Acceptance TVET Online Courses on the Skill Academy App from Google Play: Leveraging Text Mining with Comparison Machine Learning Model.

F1000Research·2026
Same journal

Emotional intelligence: An important skill to learn now more than ever.

F1000Research·2026
Same journal

East Mediterranean Lineage of <i>Brucella melitensis</i> in Human Isolates and Milk Samples in Oman Using MLVA-14.

F1000Research·2026
Same journal

Application of K-Means Clustering for Job Applicant Analysis in Construction Firms Using R.

F1000Research·2026
Same journal

The influence of self-esteem and emotional intelligence on addiction to social networks in Peruvian university students.

F1000Research·2026
See all related articles

Related Experiment Video

Updated: Dec 26, 2025

Author Spotlight: Optogenetic Inhibition of Rho1-Mediated Actomyosin Contractility Coupled with Measurement of Epithelial Tension in Drosophila Embryos
12:35

Author Spotlight: Optogenetic Inhibition of Rho1-Mediated Actomyosin Contractility Coupled with Measurement of Epithelial Tension in Drosophila Embryos

Published on: April 14, 2023

1.7K

Pulsed actomyosin contractions in morphogenesis.

Ann Sutherland1, Alyssa Lesko1

  • 1Department of Cell Biology, University of Virginia Health System, Charlottesville, VA, USA.

F1000Research
|March 10, 2020
PubMed
Summary
This summary is machine-generated.

Pulsed actomyosin contractions drive embryonic development by altering cell shape and tissue arrangement. This review explores mechanisms regulating these contractions and new methods for studying them in living organisms.

Keywords:
actomyosinapical constrictionmorphogenesispulsed contractions

More Related Videos

The Mechanics of Poro-Elastic Contractile Actomyosin Networks As a Model System of the Cell Cytoskeleton
08:50

The Mechanics of Poro-Elastic Contractile Actomyosin Networks As a Model System of the Cell Cytoskeleton

Published on: March 10, 2023

1.1K
Analysis of Actomyosin Dynamics at Local Cellular and Tissue Scales Using Time-lapse Movies of Cultured Drosophila Egg Chambers
10:45

Analysis of Actomyosin Dynamics at Local Cellular and Tissue Scales Using Time-lapse Movies of Cultured Drosophila Egg Chambers

Published on: June 3, 2019

7.7K

Related Experiment Videos

Last Updated: Dec 26, 2025

Author Spotlight: Optogenetic Inhibition of Rho1-Mediated Actomyosin Contractility Coupled with Measurement of Epithelial Tension in Drosophila Embryos
12:35

Author Spotlight: Optogenetic Inhibition of Rho1-Mediated Actomyosin Contractility Coupled with Measurement of Epithelial Tension in Drosophila Embryos

Published on: April 14, 2023

1.7K
The Mechanics of Poro-Elastic Contractile Actomyosin Networks As a Model System of the Cell Cytoskeleton
08:50

The Mechanics of Poro-Elastic Contractile Actomyosin Networks As a Model System of the Cell Cytoskeleton

Published on: March 10, 2023

1.1K
Analysis of Actomyosin Dynamics at Local Cellular and Tissue Scales Using Time-lapse Movies of Cultured Drosophila Egg Chambers
10:45

Analysis of Actomyosin Dynamics at Local Cellular and Tissue Scales Using Time-lapse Movies of Cultured Drosophila Egg Chambers

Published on: June 3, 2019

7.7K

Area of Science:

  • Developmental biology
  • Cell biology
  • Biophysics

Background:

  • Cell and tissue shape changes are crucial for embryonic development.
  • Cytoskeletal networks regulate key cellular processes like polarity, growth, apoptosis, differentiation, rearrangement, and migration.
  • Pulsed actomyosin contractions are recognized as a core mechanism for cell shape changes and rearrangement.

Purpose of the Study:

  • To review the role of pulsed actomyosin contractions in developmental morphogenesis.
  • To discuss advances in understanding the regulation of actomyosin pulsing.
  • To highlight novel techniques for studying pulsed actomyosin processes in vivo.

Main Methods:

  • Literature review of developmental biology and cell mechanics research.
  • Analysis of mechanisms controlling actomyosin contractility dynamics.
  • Exploration of cutting-edge imaging and manipulation techniques for in vivo studies.

Main Results:

  • Pulsed actomyosin contractions are fundamental to driving cell shape changes and tissue rearrangement during morphogenesis.
  • Significant progress has been made in elucidating the molecular regulators of actomyosin pulsing.
  • New in vivo techniques offer powerful tools to investigate these dynamic processes.

Conclusions:

  • Pulsed actomyosin contractions are essential drivers of morphogenesis.
  • Understanding the regulation of these contractions is key to comprehending developmental processes.
  • Emerging technologies are advancing the study of actomyosin dynamics in living systems.