Hyaluronic Acid-Cellulose Composites as Patches for Minimizing Bacterial Infections

A facile method was used to synthesize biocomposites containing differing ratios of hyaluronic acid (HA) and cellulose (CEL). Based on the properties of the individual polymers, the resultant composite materials may have potentially great wound care properties. In the method outlined here, 1-butyl-3-methylimidazolium chloride ([Bmim][Cl]), a simple ionic liquid, was used as the sole solvent without chemical modifiers to dissolve the biopolymers at ratios of 1:1 and 2:1 HA to CEL. This method was completely recyclable since the ionic liquid, [Bmim][Cl], can be recovered. Results from spectroscopic measurements [Fourier transform infrared (FT-IR) and X-ray diffraction (XRD)] confirm the interaction between HA and CEL. Scanning electron microscopy (SEM) images reflect differing biopolymer ratios and the resulting impact on the texture and porosity of these composite materials. The composites exhibited high swelling capacity in various media. These composites were also drug-loaded to examine drug release properties for greater potential in combating Staphylococcus aureus infections.