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Updated: Dec 26, 2025

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
Published on: August 22, 2018
Construction of sequence-defined polytriazoles by IrAAC and CuAAC reactions
Changhong Ju1, Congcong Meng, Jiahao Ma
1State Key Laboratory of Organic-Inorganic Composites, College of Chemical Engineering, Beijing University of Chemical Technology, Beijing, 100029, China. stding@mail.buct.edu.cn.
Abstract:
Here we report the first synthesis of sequence-defined polytriazoles, in which different side groups are sequentially anchored to the C-5 position of 1,2,3-triazole rings. By using efficient synthetic strategies based on IrAAC and CuAAC, different monodispersed polytriazoles with up to ∼5.3 kDa and 31-mer were constructed. Structural characterization via NMR, SEC, MALDI-TOF-MS, tandem MS and FTICR-MS evidenced the formation of polytriazoles with the desired specified sequences and exact chain lengths.
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