Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Residuals and Least-Squares Property01:11

Residuals and Least-Squares Property

8.8K
The vertical distance between the actual value of y and the estimated value of y. In other words, it measures the vertical distance between the actual data point and the predicted point on the line
If the observed data point lies above the line, the residual is positive, and the line underestimates the actual data value for y. If the observed data point lies below the line, the residual is negative, and the line overestimates the actual data value for y.
The process of fitting the best-fit...
8.8K
Calibration Curves: Linear Least Squares01:20

Calibration Curves: Linear Least Squares

4.0K
A calibration curve is a plot of the instrument's response against a series of known concentrations of a substance. This curve is used to set the instrument response levels, using the substance and its concentrations as standards. Alternatively, or additionally, an equation is fitted to the calibration curve plot and subsequently used to calculate the unknown concentrations of other samples reliably.
For data that follow a straight line, the standard method for fitting is the linear...
4.0K
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

1.0K
This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
1.0K
Regression Toward the Mean01:52

Regression Toward the Mean

6.8K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.8K
Linear Approximation in Frequency Domain01:26

Linear Approximation in Frequency Domain

313
Linear systems are characterized by two main properties: superposition and homogeneity. Superposition allows the response to multiple inputs to be the sum of the responses to each individual input. Homogeneity ensures that scaling an input by a scalar results in the response being scaled by the same scalar.
In contrast, nonlinear systems do not inherently possess these properties. However, for small deviations around an operating point, a nonlinear system can often be approximated as linear....
313
Linear Approximation in Time Domain01:21

Linear Approximation in Time Domain

281
Nonlinear systems often require sophisticated approaches for accurate modeling and analysis, with state-space representation being particularly effective. This method is especially useful for systems where variables and parameters vary with time or operating conditions, such as in a simple pendulum or a translational mechanical system with nonlinear springs.
For a simple pendulum with a mass evenly distributed along its length and the center of mass located at half the pendulum's length,...
281

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Design, synthesis, biological evaluation, DFT and molecular docking studies of novel isoxazolines containing cyclic amide.

Bioorganic chemistry·2026
Same author

Air-permeable hydrogels through viscoelastic phase separation of aerogels.

Nature·2026
Same author

Post-stroke acute heart failure in patients with large vessel occlusion undergoing endovascular treatment: A pooled analysis of individual patient data from multicenter studies with mediation analysis.

PLoS medicine·2026
Same author

High-definition transcranial direct current stimulation enhances exercise-induced hypoalgesia in patients with chronic low back pain.

iScience·2026
Same author

PEGylated thymosin β4 is a thiol-site-specific prodrug treating myocardial infarction in vivo.

Bioengineering & translational medicine·2026
Same author

Targeting SLK protects against cerebral ischemia-reperfusion injury by regulating USP8-mediated HIF-1α stabilization and RhoA/ROCK activation.

Cellular & molecular biology letters·2026

Related Experiment Video

Updated: Dec 26, 2025

Visualization Method for Proprioceptive Drift on a 2D Plane Using Support Vector Machine
07:05

Visualization Method for Proprioceptive Drift on a 2D Plane Using Support Vector Machine

Published on: October 27, 2016

9.5K

Laplacian Welsch Regularization for Robust Semisupervised Learning.

Jingchen Ke, Chen Gong, Tongliang Liu

    IEEE Transactions on Cybernetics
    |March 10, 2020
    PubMed
    Summary
    This summary is machine-generated.

    This study introduces Laplacian Welsch regularization (LapWR), a novel semisupervised learning (SSL) algorithm. LapWR enhances robustness to outliers in labeled data, achieving top-level results on benchmark datasets.

    More Related Videos

    Deep Neural Networks for Image-Based Dietary Assessment
    13:19

    Deep Neural Networks for Image-Based Dietary Assessment

    Published on: March 13, 2021

    9.8K

    Related Experiment Videos

    Last Updated: Dec 26, 2025

    Visualization Method for Proprioceptive Drift on a 2D Plane Using Support Vector Machine
    07:05

    Visualization Method for Proprioceptive Drift on a 2D Plane Using Support Vector Machine

    Published on: October 27, 2016

    9.5K
    Deep Neural Networks for Image-Based Dietary Assessment
    13:19

    Deep Neural Networks for Image-Based Dietary Assessment

    Published on: March 13, 2021

    9.8K

    Area of Science:

    • Machine Learning
    • Artificial Intelligence
    • Data Science

    Background:

    • Semisupervised learning (SSL) is crucial when labeled data is scarce but unlabeled data is abundant.
    • Existing SSL methods are vulnerable to outliers in limited labeled data, compromising classifier performance.
    • Robustness to outliers is a key challenge in practical SSL applications.

    Purpose of the Study:

    • To propose a novel SSL algorithm, Laplacian Welsch regularization (LapWR), to improve robustness against outliers.
    • To introduce a bounded, smooth, and nonconvex Welsch loss function to mitigate outlier effects.
    • To provide theoretical guarantees and demonstrate empirical superiority of the proposed method.

    Main Methods:

    • Laplacian Welsch regularization (LapWR) incorporating a Welsch loss function.
    • Iterative half-quadratic (HQ) optimization to handle model nonconvexity.
    • Nyström method for computational efficiency on large datasets.
    • Rademacher complexity analysis for theoretical generalization bounds.

    Main Results:

    • LapWR demonstrates significant robustness to outliers in labeled data.
    • The proposed algorithm consistently achieves top-level performance across benchmark and real-world datasets.
    • The Welsch loss effectively suppresses the adverse impact of outliers.
    • The accelerated model maintains performance while reducing computational complexity.

    Conclusions:

    • Laplacian Welsch regularization (LapWR) offers a robust and effective solution for semisupervised learning with outlier-corrupted labeled data.
    • The method provides theoretical guarantees and strong empirical evidence of its effectiveness.
    • LapWR represents a significant advancement in developing reliable SSL algorithms for practical applications.