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Published on: June 2, 2014
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The functional alterations in primary migraine: A systematic review and meta-analysis protocol
Guixing Xu1, Shirui Cheng1, Yuzhu Qu1,2
1The Acupuncture and Tuina School, The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine.
Medicine
|March 10, 2020
Summary
This meta-analysis investigates functional brain changes in migraine patients using neuroimaging. It aims to clarify conflicting findings and provide a clear understanding of cerebral alterations in migraine.
Area of Science:
- Neuroscience
- Medical Imaging
Background:
- Neuroimaging studies reveal altered brain activity in migraineurs, but findings vary.
- Discrepancies necessitate a comprehensive review of existing evidence.
Purpose of the Study:
- To investigate concurrence across neuroimaging studies on migraine.
- To verify functional cerebral alterations in migraine patients based on the latest evidence.
Main Methods:
- Coordinate-based meta-analysis using Anisotropic effect size version of signed differential mapping (AES-SDM).
- Systematic search of EMBASE, Cochrane Library, PubMed, and Web of Science databases up to June 2019.
- Quality assessment using Newcastle-Ottawa Scale (NOS) and publication bias assessment via Egger test.
Main Results:
- This study is expected to deepen the understanding of functional cerebral alterations in migraine.
Conclusions:
- The study will offer a clear conclusion on functional cerebral alterations in migraine patients.
- Findings will be based on a synthesis of the latest available evidence.
