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Updated: Dec 26, 2025

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Multiscale brain research on a microfluidic chip.

Yanan Zhao1, Utkan Demirci, Yun Chen

  • 1Department of Biomedical Engineering, Wuhan University School of Basic Medical Sciences, 115 Donghu Road, Wuhan 430071, China. yunchen@whu.edu.cn puchen@whu.edu.cn.

Lab on a Chip
|March 10, 2020
PubMed
Summary
This summary is machine-generated.

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Microfluidic chips (μFCs) are advancing brain research by enabling studies across multiple scales, from molecules to organisms. These neurotechnologies offer novel solutions for understanding brain functions and disorders.

Area of Science:

  • Neuroscience
  • Bioengineering
  • Biotechnology

Background:

  • Understanding brain function and disorders requires integrating multiscale neuronal architecture and connectivity.
  • Current neurotechnology tools face challenges in deciphering brain organization across molecular to organismal levels.
  • Global research initiatives highlight the urgent need for innovative tools in brain research.

Purpose of the Study:

  • To review the progress of microfluidic chip (μFC)-based neurotechnologies for multiscale brain research.
  • To focus on representative applications of μFCs addressing challenges at each hierarchical level of brain organization.
  • To discuss the integration of μFCs with other technologies and identify future research directions.

Main Methods:

  • Review of recent advancements in microfluidic chip (μFC) applications for neurotechnology.

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Last Updated: Dec 26, 2025

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  • Focus on μFCs enabling trans-scale studies of brain structure and function.
  • Discussion of combinational applications of μFCs with optogenetics, brain organoids, and 3D bioprinting.

    • Main Results:

    • Microfluidic chips (μFCs) offer advantages in microstructure design, multifunctional integration, microenvironment control, and automated processing for brain research.
    • μFCs are being applied to address challenges at various hierarchical levels of brain organization.
    • Combinations of μFCs with other advanced technologies enhance multiscale brain research capabilities.

    Conclusions:

    • Microfluidic chip (μFC) technology is a rapidly evolving neurotechnological toolset for multiscale brain research.
    • Further advancements in microfluidic techniques can address outstanding questions in brain research across all hierarchical levels.
    • This review serves as a guide for developing and applying μFC-based neurotechnologies in basic and translational research.