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Toward best practice methods for delirium biomarker studies: An international modified Delphi study
Ingrid Amgarth-Duff1, Annmarie Hosie1,2, Gideon Caplan3,4
1IMPACCT (Improving Palliative, Aged and Chronic Care through Clinical Research and Translation), University of Technology Sydney, Sydney, New South Wales, Australia.
International Journal of Geriatric Psychiatry
|March 10, 2020
Summary
Researchers developed consensus on 60 core elements for high-quality delirium biomarker studies. This aims to improve the understanding of delirium pathophysiology and guide future research in neurocognitive conditions.
Area of Science:
- Neuroscience
- Biomarker Research
- Clinical Trials
Background:
- Delirium is a prevalent and distressing neurocognitive condition in advanced illness.
- Current understanding of delirium pathophysiology is limited and largely hypothetical.
- There is an urgent need for robust methods in delirium biomarker studies.
Purpose of the Study:
- To establish international consensus on essential components for high-quality delirium biomarker studies.
- To enhance the methodological rigor of research investigating delirium.
- To facilitate the synthesis of findings from future delirium biomarker investigations.
Main Methods:
- A three-round modified Delphi survey was employed from February to August 2019.
- International researchers with expertise in delirium studies participated.
- Consensus was defined as ≥70% agreement, with items ranked using a 5-point Likert scale.
Main Results:
- Sixty items achieved international expert consensus.
- The survey involved 28 participants in round one, 16 in round two, and 19 in round three.
- Key elements for conducting and reporting delirium biomarker studies were identified.
Conclusions:
- The Delphi survey successfully identified critical items for delirium biomarker studies.
- These consensus-based reporting items will improve study quality.
- The findings provide a foundation for synthesizing future delirium biomarker research.
