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Related Experiment Video

Updated: Dec 26, 2025

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Full-Process Radiosensitization Based on Nanoscale Metal-Organic Frameworks.

Teng Gong1, Yanli Li1, Bin Lv2

  • 1Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China.

ACS Nano
|March 10, 2020
PubMed
Summary

This study introduces Hf-nMOFs (hafnium-based nano-metal-organic frameworks) to enhance cancer radiotherapy. These materials boost radiosensitivity by increasing reactive oxygen species and interfering with DNA repair, leading to improved tumor cell death.

Keywords:
chemodynamic therapyfull-process radiosensitizationhydroxyl radicalsmetal−organic frameworksradiotherapy

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Area of Science:

  • Nanomaterials in Radiotherapy
  • Cancer Treatment
  • Metal-Organic Frameworks (MOFs)

Background:

  • Full-process radiosensitization remains a challenge in enhancing radiotherapy efficacy.
  • Current strategies struggle to integrate pre-irradiation sensitivity enhancement, reactive oxygen species (ROS) generation, and DNA repair intervention.
  • There is a need for novel materials that can achieve comprehensive radiosensitization.

Purpose of the Study:

  • To develop and evaluate hafnium-based nano-metal-organic frameworks (Hf-nMOFs) for integrated radiosensitization.
  • To investigate the multifaceted mechanism of Hf-nMOFs in improving radiotherapeutic effects.
  • To assess the efficacy of Hf-nMOFs in enhancing tumor cell death and radiosensitivity.

Main Methods:

  • Construction of Hf-nMOFs with uniformly dispersed Fe3+ ions (Hf-BPY-Fe).
  • In vitro studies to assess ROS generation, cell cycle distribution, and DNA repair interference.
  • In vivo experiments to evaluate the therapeutic effects of Hf-BPY-Fe combined with photon radiation.

Main Results:

  • Hf-BPY-Fe activated in situ Fenton reactions, increasing ROS stress and tumor radiosensitivity.
  • Hf4+ in Hf-BPY-Fe facilitated X-ray energy conversion, promoting •OH production and Fe3+ reduction.
  • Hf-BPY-Fe interfered with DNA repair pathways, delaying damage response and enhancing cell death.
  • In vivo studies demonstrated improved radiotherapeutic effects due to combined Fenton reaction and X-ray energy conversion.

Conclusions:

  • Hf-nMOFs offer a promising platform for full-process radiosensitization in cancer therapy.
  • The integrated mechanism involving ROS generation and DNA repair intervention significantly enhances radiotherapeutic efficacy.
  • This study presents a novel nMOF-based approach for improved cancer radiotherapy outcomes.