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Current Status of Mumps Virus Infection: Epidemiology, Pathogenesis, and Vaccine

Shih-Bin Su1, Hsiao-Liang Chang2, And Kow-Tong Chen3,4

  • 1Department of Occupational Medicine, Chi-Mei Medical Center, Tainan, 710, Taiwan.

International Journal of Environmental Research and Public Health
|March 11, 2020
PubMed

Insights

Mumps virus (MuV) infections decreased with vaccination, but recent resurgences highlight the need for effective mumps vaccines and public health strategies. Booster MMR vaccine doses are recommended during outbreaks.

Area of Science:

  • Virology
  • Epidemiology
  • Immunology

Background:

  • Mumps is a significant childhood infectious disease caused by the mumps virus (MuV).
  • Global incidence of mumps sharply declined following the widespread introduction of the mumps vaccine.

Purpose of the Study:

  • To review the epidemiology, pathogenesis, and vaccine development of mumps.
  • To assess the current challenges and strategies for controlling mumps infections.

Main Methods:

  • A comprehensive literature search was conducted using keywords such as "mumps", "epidemiology", "pathogenesis", and "vaccine".
  • Databases searched included MEDLINE, PubMed, Embase, Web of Science, and Google Scholar.
  • Articles were excluded if not in English, lacking abstracts, or were opinion pieces.

Main Results:

  • The mumps vaccine significantly reduced MuV cases globally.
  • Recent years have seen a resurgence of mumps in developed nations, with some vaccine strains linked to aseptic meningitis.
  • Vaccine performance is critical for controlling mumps infections.

Conclusions:

  • Vaccine development and routine immunization remain crucial for reducing global mumps incidence.
  • Enhanced vaccination strategies, including booster doses during outbreaks, are essential for managing mumps resurgence.
Keywords:
epidemiologymumpspathogenesisvaccine

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