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Old drugs, new uses: Drug repurposing in hematological malignancies

Vijay P Kale1, Hasan Habib2, Robert Chitren3

  • 1Clinical and Nonclinical Research, Battelle Memorial Institute, Columbus, OH, USA.

Seminars in Cancer Biology
|March 11, 2020
PubMed

Insights

Drug repurposing offers a faster, cheaper way to find new treatments for blood cancers. This review explores existing non-cancer drugs that could be repurposed for hematological malignancies, saving time and cost.

Area of Science:

  • Oncology
  • Pharmacology
  • Systems Biology

Background:

  • Novel anti-cancer drug development is costly and time-intensive.
  • Systems biology reveals that drugs developed for non-cancer indications can target cancer pathways.
  • Repurposing existing drugs significantly reduces development costs and timelines, as exemplified by thalidomide.

Purpose of the Study:

  • To review existing non-cancer drugs for their potential repurposing in treating hematological malignancies.
  • To identify and discuss resources that facilitate drug repurposing for blood cancers.

Main Methods:

  • Literature review of drugs developed for non-cancer indications.
  • Analysis of drug targets and pathways relevant to hematological malignancies.
  • Identification of potential drug candidates for repurposing.

Main Results:

  • Several non-cancer drugs show promise for treating hematological malignancies.
  • Drug repurposing presents a viable strategy to accelerate treatment development.
  • Resources for drug repurposing are cataloged.

Conclusions:

  • Drug repurposing is an efficient strategy to develop new therapies for hematological malignancies.
  • Exploring non-cancer drugs can lead to cost-effective and faster treatment options.
  • This approach can significantly benefit patients with blood cancers by reducing development time and cost.
Keywords:
Drug developmentDrug repositioningDrug repurposingHematological malignanciesMultiple myeloma

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