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Blood pressure variability and outcome after acute intracerebral hemorrhage

Mostafa Jafari1, Rahul Damani2

  • 1Department of Neurology, Baylor College of Medicine, Houston, TX, USA.

Journal of the Neurological Sciences
|March 11, 2020
PubMed

Intracerebral hemorrhage (ICH) is life threatening neurologic event that results in significant rate of morbidity and mortality. Unfortunately, several randomized clinical trials aiming at limiting the hematoma expansion (HE) in the acute phase of ICH have not shown significant effects in improving the functional outcomes. Blood pressure variability (BPV) is common following ICH. High BPs have been associated with increased risk of bleeding and HE. Conversely, recurrent sudden decrease in BP promote perihematomal ischemia. However, it is still not clear weather BPV causes adverse prognosis following ICH or large ICHs cause fluctuations in BP. In the current review, we will discuss the mechanistic pathophysiology of BPV and the evidence regarding the role of BPV on the ICH outcomes.

Keywords:
Blood pressure variabilityHematoma expansionIntracerebral hemorrhage

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