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Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
Published on: June 22, 2016
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TIGIT limits immune pathology during viral infections
Michelle Schorer1, Nikolas Rakebrandt1, Katharina Lambert1
1Institute of Experimental Immunology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
Nature Communications
|March 11, 2020
Summary
The TIGIT pathway regulates T cell responses and immune pathology. Modulating TIGIT limits immune damage in peripheral organs by inducing IL-10, independent of viral clearance.
Area of Science:
- Immunology
- Virology
Background:
- Co-inhibitory pathways regulate T cell responses, balancing effector functions and immune pathology.
- The TIGIT pathway is linked to T cell dysfunction in chronic viral infections and IL-10 expression, impacting virus control and tissue homeostasis.
Purpose of the Study:
- To investigate the role of TIGIT in viral persistence and limiting tissue pathology during viral infections.
- To determine if TIGIT modulation affects T cell phenotype, cytokine profiles, and virus control in vivo.
Main Methods:
- TIGIT modulation was studied in mouse models of influenza and chronic lymphocytic choriomeningitis virus (LCMV) infection.
- Analysis included T cell phenotype, cytokine profiles (e.g., IL-10), and assessment of virus control and immune pathology.
Main Results:
- TIGIT modulation altered T cell phenotype and cytokine profiles during influenza and LCMV infections.
- TIGIT modulation did not affect virus control in vivo.
- TIGIT was found to limit immune pathology in peripheral organs through IL-10 induction.
Conclusions:
- TIGIT plays a crucial role in limiting immune pathology during viral infections.
- This protective function of TIGIT is independent of viral clearance and mediated by IL-10 induction.
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