Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is Genetic Engineering?00:49

What is Genetic Engineering?

79.4K
Overview
79.4K
Replication in Eukaryotes01:29

Replication in Eukaryotes

16.8K
In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
16.8K
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

8.9K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
8.9K
CRISPR01:59

CRISPR

57.3K
Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
57.3K
Human Genetics01:28

Human Genetics

1.3K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.3K
Meiosis I03:09

Meiosis I

43.6K
Meiosis is the division of a diploid cell into haploid cells forming sperm and eggs in animals through differentiation. Meiosis I is the first stage of meiosis, where the genetic recombination of homologous chromosomes and the reduction of the ploidy level by half occurs.
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...
43.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Toward an Africanized Bioethics Curriculum.

Cambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees·2020
Same author

On the moral status of hominins.

Monash bioethics review·2019
See all related articles

Related Experiment Video

Updated: Dec 26, 2025

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

6.7K

Genome Editing for Longer Lives: The Problem of Loneliness.

C S Wareham1

  • 1Steve Biko Centre for Bioethics, University of the Witwatersrand, Rm 312, 3rd floor, P.V. Tobias Building, Cnr Carse O'Gowrie and York Road, Parktown, Johannesburg, 2193, South Africa. Christopher.wareham@wits.ac.za.

Journal of Bioethical Inquiry
|March 11, 2020
PubMed
Summary

Gene-editing technologies like CRISPR/Cas9 offer potential to extend human lifespan. However, this essay argues against the ethical objection that lifespan extension via germline editing causes loneliness in future generations.

Keywords:
Ageing ethicsEnhancementGene-editingLife extensionLoneliness

More Related Videos

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
10:08

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Published on: May 18, 2022

3.9K
Combining Magnetic Sorting of Mother Cells and Fluctuation Tests to Analyze Genome Instability During Mitotic Cell Aging in Saccharomyces cerevisiae
11:08

Combining Magnetic Sorting of Mother Cells and Fluctuation Tests to Analyze Genome Instability During Mitotic Cell Aging in Saccharomyces cerevisiae

Published on: October 16, 2014

12.8K

Related Experiment Videos

Last Updated: Dec 26, 2025

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

6.7K
Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
10:08

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Published on: May 18, 2022

3.9K
Combining Magnetic Sorting of Mother Cells and Fluctuation Tests to Analyze Genome Instability During Mitotic Cell Aging in Saccharomyces cerevisiae
11:08

Combining Magnetic Sorting of Mother Cells and Fluctuation Tests to Analyze Genome Instability During Mitotic Cell Aging in Saccharomyces cerevisiae

Published on: October 16, 2014

12.8K

Area of Science:

  • Genetics
  • Bioethics
  • Longevity research

Background:

  • Gene-editing technologies, including CRISPR/Cas9, are advancing rapidly.
  • Understanding of genetic factors in human aging is expanding.
  • Potential exists to use gene editing for lifespan extension and treating genetic disorders.

Purpose of the Study:

  • To examine a specific ethical objection to extending human lifespan through germline gene editing.
  • To analyze the argument that lifespan extension unethically inflicts loneliness on future generations.

Main Methods:

  • Philosophical analysis of ethical arguments.
  • Examination of assumptions underlying objections to germline editing for longevity.

Main Results:

  • The ethical objection based on loneliness is critically assessed.
  • The assumptions supporting this objection are identified as questionable.

Conclusions:

  • The ethical argument that germline gene editing for lifespan extension causes loneliness is not sufficiently robust.
  • Further ethical considerations are needed for germline editing applications in human longevity.