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Natural products as promising targets in glioblastoma multiforme: a focus on NF-κB signaling pathway
Mohammad Soukhtanloo1, Elmira Mohtashami2, Abolfazl Maghrouni3
1Department of Medical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Background:
Glioblastoma multiforme (GBM), as the broadest cerebrum tumor, is resistant to current medical interventions, particularly chemo/radiation. Hence, it necessitates further therapeutic options that could enhance the efficacy of existing modalities.
Methods:
A comprehensive and systematic review of literature on the NF-κB signaling pathway-contributed in the pathogenesis of GBM with a focus on natural products was carried out.
Results:
Several examinations have shown that nuclear factor (NF)-κB is participated in apoptosis, cellular proliferation, angiogenesis, metastasis, invasion, and many other processes implicated in GBM pathobiology. Recent studies have provided that NF-κB regulation is the primary pharmacological target for GBM therapy. Specific natural products are involved in several signaling pathways implicated in tumor growth and apoptosis of GBM cells.
Conclusion:
In the current review, we elaborate on the role of NF-κB as a promising target in GBM and discuss some natural products affecting the NF-κB signaling pathway.
Insights
Glioblastoma multiforme (GBM) is a challenging brain tumor. Natural products targeting the NF-κB pathway offer a promising therapeutic strategy to enhance GBM treatment efficacy.
Area of Science:
- Oncology
- Molecular Biology
- Pharmacology
Background:
- Glioblastoma multiforme (GBM) is an aggressive brain tumor.
- GBM exhibits resistance to conventional chemo/radiation therapies.
- Novel therapeutic strategies are crucial for improving GBM treatment outcomes.
Purpose of the Study:
- To review the role of the NF-κB signaling pathway in GBM pathogenesis.
- To explore natural products as potential therapeutic agents targeting NF-κB in GBM.
- To identify novel therapeutic avenues for GBM treatment.
Main Methods:
- Systematic literature review.
- Focused on NF-κB signaling pathway in GBM.
- Investigated the impact of natural products on this pathway.
Main Results:
- NF-κB is implicated in key GBM processes like proliferation, apoptosis, and metastasis.
- NF-κB regulation is a key pharmacological target for GBM therapy.
- Certain natural products modulate signaling pathways crucial for GBM cell growth and survival.
Conclusions:
- The NF-κB signaling pathway presents a promising therapeutic target for GBM.
- Natural products modulating NF-κB signaling warrant further investigation for GBM treatment.
- This review highlights potential natural product-based therapies to enhance GBM management.
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