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Siglecs that Associate with DAP12.

Takashi Angata1

  • 1Institute of Biological Chemistry, Academia Sinica, 128, Section 2, Academia Road, Nangang District, Taipei, Taiwan. angata@gate.sinica.edu.tw.

Advances in Experimental Medicine and Biology
|March 11, 2020
PubMed
Summary
This summary is machine-generated.

Sialic acid-binding immunoglobulin-like lectins (Siglecs) are key leukocyte receptors. DAP12-associated Siglecs have diverse roles in immunity and bone homeostasis, with potential implications for host defense and disease resistance.

Keywords:
DAP12ITAMPaired receptorsSiglecSyk

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Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • Siglecs are transmembrane glycan-binding proteins on leukocytes.
  • Most Siglecs use ITIM motifs to inhibit signaling via SHP-1.
  • Some Siglecs associate with DAP12 and Syk, mediating distinct functions.

Purpose of the Study:

  • To review the diverse functions of DAP12-associated Siglecs.
  • To highlight their roles in bone homeostasis and immunity.
  • To discuss the implications of Siglec polymorphisms in host defense.

Main Methods:

  • Review of existing literature on Siglec structure and function.
  • Analysis of Siglec roles in bone homeostasis (e.g., Siglec-15).
  • Examination of paired receptor systems and their evolutionary significance.

Main Results:

  • DAP12-associated Siglecs, like Siglec-15, regulate osteoclast function.
  • Paired Siglec receptors (e.g., Siglec-14/Siglec-5) exhibit functional antagonism.
  • Siglec polymorphisms influence susceptibility to bacterial infections.

Conclusions:

  • DAP12-associated Siglecs are crucial for immune regulation and bone metabolism.
  • Understanding these receptors offers insights into host-pathogen interactions.
  • Further research on DAP12-associated Siglecs has translational potential for disease treatment.