Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prefrontal stimulus-produced hypotension in rat.

S G Hardy1, D E Holmes

  • 1Department of Anatomy, University of Mississippi Medical Center, Jackson 39216.

Experimental Brain Research
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biologically Produced Methane as a Renewable Energy Source.

Advances in applied microbiology·2016
Same author

Proteins involved in electron transfer to Fe(III) and Mn(IV) oxides by Geobacter sulfurreducens and Geobacter uraniireducens.

Microbiology (Reading, England)·2013
Same author

The new genetics-challenges and consequences of therapeutic developments.

The Western journal of medicine·2008
Same author

Molecular analysis of a sulphate-reducing consortium used to treat metal-containing effluents.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine·2006
Same author

Microbial communities associated with electrodes harvesting electricity from a variety of aquatic sediments.

Microbial ecology·2004
Same author

Hypothalamic projections to cardiovascular centers of the medulla.

Brain research·2001

Electrical stimulation of rat frontal cortex can cause hypotension and bradycardia. This stimulus-produced hypotension is not vagus nerve-mediated but may involve sympathetic inhibition and opioid pathways.

Area of Science:

  • Neuroscience
  • Cardiovascular Physiology

Background:

  • The frontal cortex plays a role in regulating autonomic functions.
  • Understanding the neural pathways involved in cardiovascular control is crucial.

Purpose of the Study:

  • To investigate the effects of electrical stimulation of different frontal cortex regions on blood pressure and heart rate in rats.
  • To elucidate the neural mechanisms underlying stimulus-produced hypotension (SPH).

Main Methods:

  • Bipolar electrical stimulation of medial prefrontal cortex (MPFC), lateral prefrontal cortex (LPFC), infralimbic cortex, and convexity cortex in rats.
  • Monitoring of blood pressure and heart rate.
  • Pharmacological and surgical blockade of vagus nerves.
  • Administration of norepinephrine and naloxone.

Related Experiment Videos

Main Results:

  • Stimulation of LPFC, infralimbic cortex, and ventral MPFC induced hypotension.
  • LPFC stimulation caused bradycardia; MPFC and infralimbic cortex stimulation had minimal heart rate effects.
  • Vagus nerve blocks did not alter SPH.
  • Norepinephrine and naloxone administration completely blocked SPH.

Conclusions:

  • Stimulus-produced hypotension in rats is not mediated by vagus nerves.
  • SPH may result from sympathetic inhibition.
  • Opioid pathways may play a role in mediating SPH.