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Asprosin: A Novel Player in Metabolic Diseases
Mingyang Yuan1, Weidong Li1, Yan Zhu1
1Department of Endocrinology, Xiangya Hospital, Central South University, Changsha, China.
Frontiers in Endocrinology
|March 11, 2020
Summary
Asprosin, a novel adipokine from Fibrillin 1 (FBN1) gene, impacts appetite and glucose metabolism. This review explores its roles in metabolic diseases like diabetes, obesity, PCOS, and CVD for potential clinical applications.
Area of Science:
- Endocrinology
- Metabolic Research
- Molecular Biology
Background:
- Asprosin is a newly identified glucogenic adipokine synthesized by white adipose tissue during fasting.
- It originates from exons 65 and 66 of the Fibrillin 1 (FBN1) gene.
- Asprosin influences the central nervous system, peripheral tissues, and organs, affecting key physiological processes.
Purpose of the Study:
- To review the emerging roles of asprosin in metabolic diseases.
- To highlight asprosin's involvement in conditions such as diabetes, obesity, polycystic ovarian syndrome (PCOS), and cardiovascular disease (CVD).
- To discuss the potential of asprosin as a target for future clinical diagnosis and treatment strategies.
Main Methods:
- Literature review of recent studies on asprosin.
- Analysis of asprosin's molecular functions and pathways.
- Synthesis of findings related to asprosin and metabolic disorders.
Main Results:
- Asprosin is implicated in regulating appetite and glucose metabolism.
- It plays a role in insulin resistance (IR) and cellular apoptosis.
- Emerging evidence links asprosin to the pathogenesis of diabetes, obesity, PCOS, and CVD.
Conclusions:
- Asprosin is a significant adipokine with diverse roles in metabolic regulation.
- Understanding asprosin's functions is crucial for developing novel therapeutic approaches for metabolic diseases.
- Further research into asprosin may lead to improved clinical diagnostic and treatment options.
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