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The Role of Promyelocytic Leukemia Nuclear Bodies During HPV Infection

Lucile G Guion1,2, Martin Sapp1,2

  • 1Department of Microbiology and Immunology, Center for Molecular and Tumor Virology, Louisiana State University Health Sciences Center, Shreveport, LA, United States.

Frontiers in Cellular and Infection Microbiology
|March 11, 2020
PubMed

Insights

Promyelocytic leukemia (PML) nuclear bodies (NBs) are dynamic structures crucial for cellular processes. This review explores their role in human papillomavirus (HPV) infection, highlighting PML protein

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Virology

Background:

  • Promyelocytic leukemia (PML) nuclear bodies (NBs) are dynamic subnuclear structures essential for cellular functions.
  • PML protein, its isoforms, Sp100, and DAXX are key components of PML NBs.
  • PML NBs undergo dynamic changes during the cell cycle and are involved in various cellular processes.

Purpose of the Study:

  • To review recent advances in understanding the role of PML NBs in human papillomavirus (HPV) infection.
  • To discuss the function of individual protein components within PML NBs during HPV infection establishment.

Main Methods:

  • Literature review of recent scientific advances.
  • Synthesis of current knowledge on PML NBs and their interaction with viruses.
  • Analysis of the role of PML protein in HPV infection.

Main Results:

  • PML NBs are implicated in apoptosis, transcriptional regulation, DNA repair, and replication.
  • Many viruses target PML NBs, but HPV infection requires PML protein presence.
  • PML NBs may be essential for establishing HPV infection.

Conclusions:

  • PML NBs play a complex role in cellular processes and viral interactions.
  • The specific function of PML NBs in HPV infection establishment is an active area of research.
  • Further investigation into PML NBs and their protein components is crucial for understanding HPV pathogenesis.
Keywords:
HPV—human papillomavirusInnate immnuityL2 proteinPMLPML nuclear bodiesinfectious entrytranscription

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