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Aberrant Epithelial Cell Proliferation in Peripheral Airways in Bronchiectasis.

Yang Peng1,2, Ai-Ru Xu1, Shi-Ying Chen1

  • 1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.

Frontiers in Cell and Developmental Biology
|March 11, 2020
PubMed
Summary

Aberrant proliferation of airway progenitor cells, including thyroid transcription factor-1 (TTF-1) expressing cells, contributes to bronchiectasis. This study found altered progenitor cell expression in dilated bronchioles, implicating them in the disease pathology.

Keywords:
bronchiectasisbronchioleepitheliumhyperplasiaprogenitor cells

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