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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

266
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
266
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

237
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
237
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

263
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
263

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Updated: Dec 26, 2025

Orthotopic Kidney Auto-Transplantation in a Porcine Model Using 24 Hours Organ Preservation And Continuous Telemetry
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APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO): Design and Rationale.

Barry I Freedman1, Marva M Moxey-Mims2, Amir A Alexander3

  • 1Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.

Kidney International Reports
|March 11, 2020
PubMed
Summary
This summary is machine-generated.

The APOLLO study investigates how the APOL1 gene impacts kidney transplant outcomes in African Americans. Understanding APOL1 genotypes can improve donor kidney quality and transplant success rates.

Keywords:
APOL1African Americanschronic kidney diseasegraft failurekidney transplantationoutcomes

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Area of Science:

  • Nephrology
  • Genetics
  • Transplantation Immunology

Background:

  • African American individuals face a higher risk of end-stage kidney disease (ESKD) linked to APOL1 gene variations.
  • Kidneys from African American donors show reduced allograft survival compared to European American donors.
  • Living kidney donors of African ancestry have a higher incidence of developing ESKD.

Purpose of the Study:

  • To prospectively assess kidney allograft survival based on donor and recipient APOL1 genotypes in individuals with recent African ancestry.
  • To evaluate the impact of APOL1 genetic variations on kidney transplantation outcomes.
  • To inform strategies for improving kidney donor quality and transplant safety.

Main Methods:

  • The APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) study is an observational study.
  • Evaluating outcomes from 2614 deceased kidney donor-recipient pairs and additional living donor pairs.
  • Utilizing data provided by the United Network for Organ Sharing (UNOS) for analyses.

Main Results:

  • The study involves extensive collaboration with national transplant organizations and programs.
  • A Community Advisory Council of individuals with kidney disease history provides guidance.
  • APOLLO employs a central institutional review board (cIRB) and voluntary partnerships.

Conclusions:

  • Results will guide the use of APOL1 genotypic data to enhance deceased-donor kidney quality assessment.
  • Potential to increase kidney transplantation numbers and reduce organ discard rates.
  • Aims to improve the safety of living kidney donation through genetic insights.