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Related Experiment Video

Updated: Dec 26, 2025

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness

Published on: September 28, 2022

Deterministic epidemic model for ( ) pneumonia dynamics, with vaccination and temporal immunity.

Dominic Otoo^1,2, Patrick Opoku^1,2, Sebil Charles²

¹Department of Mathematics & Statistics, School of Science, University of Energy & Natural Resources, Sunyani, Ghana.

Infectious Disease Modelling

|March 11, 2020

Summary

Effective vaccination can eradicate Streptococcus pneumoniae infections in the long term. This study models bacterial pneumonia spread and control, highlighting vaccination

Keywords:

Asymptomatic carriers Morbidity Mortality Pneumonia Symptomatic carriers Vaccination

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Area of Science:

Mathematical modeling
Epidemiology
Public Health

Background:

Streptococcus pneumoniae causes significant childhood and elderly mortality, particularly in developing nations like Ghana.
Pneumonia remains a critical global health challenge, necessitating effective control strategies.

Purpose of the Study:

To formulate and analyze a mathematical model for bacterial pneumonia transmission.
To evaluate the impact of vaccination interventions on pneumonia spread and control.

Main Methods:

Mathematical modeling of disease dynamics including symptomatic and asymptomatic carriers.
Analysis of disease-free and endemic equilibria using the basic reproductive number.
Numerical simulations to assess vaccination intervention effectiveness.

Main Results:

The disease-free equilibrium is stable when the basic reproductive number is less than 1.
The endemic equilibrium is globally stable, indicating disease persistence when the basic reproductive number is greater than 1.
Numerical simulations demonstrate that effective vaccination can lead to long-term eradication of pneumonia.

Conclusions:

Vaccination is a crucial intervention for controlling and potentially eradicating Streptococcus pneumoniae infections.
Mathematical modeling provides valuable insights into disease dynamics and the impact of public health strategies.
Targeted vaccination programs are essential for reducing the burden of pneumonia in vulnerable populations.