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Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula

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Lichenochemicals: extraction, purification, characterization, and application as potential anticancer agents.

Mahshid Mohammadi¹, Vasudeo Zambare^1,2, Ladislav Malek^1,3

¹Biorefining Research Institute, Lakehead University, Thunder Bay, Ontario, Canada.

Expert Opinion on Drug Discovery

|March 11, 2020

Summary

Lichens contain over 1,000 secondary metabolites with potential anticancer properties. Research is limited by isolation challenges and understanding mechanisms, but new methods offer promise for drug discovery.

Keywords:

Anticancer agents DNA fragmentation antiproliferation apoptosis cancer cell lines cytotoxicity extraction lichenochemicals lichens secondary metabolites

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Area of Science:

Natural Product Chemistry
Pharmacology
Drug Discovery

Background:

Over 1,000 lichen secondary metabolites identified, with promising cytotoxic properties.
Limited literature on anticancer evaluation of lichen-derived compounds (lichenochemicals).
Increasing cancer prevalence fuels interest in lichens for anti-cancer drug development.

Purpose of the Study:

Review challenges in lichen anticancer research.
Discuss limitations and advantages of methods for lichen exploration and screening.
Highlight potential of lichen secondary metabolites for anti-cancer drug discovery.

Main Methods:

Systematic review of existing literature.
Analysis of challenges in compound isolation, characterization, and mechanism of action studies.
Evaluation of commonly used and novel screening methods for lichen metabolites.

Main Results:

Lichen secondary metabolites demonstrate chemotherapeutic potential.
Challenges include low cytotoxic compound levels, technical isolation difficulties, and poor understanding of mechanisms.
New methods are being developed for lichen exploration and screening.

Conclusions:

A multidisciplinary approach is crucial for advancing lichen research.
Further investigation is needed to understand the cytotoxic mechanisms of lichenochemicals.
Focus on screening and discovering novel lichen-derived compounds with unique anticancer properties is essential.