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Published on: May 21, 2019
Three-Component Minisci Reaction with 1,3-Dicarbonyl Compounds Induced by Visible Light
Tao Li1, Kangjiang Liang1, Yang Zhang1
1Key Laboratory of Medicinal Chemistry for Natural Resource (Ministry of Education and Yunnan Province), School of Chemical Science and Technology, and Yunnan University Library, Yunnan University, 2 North Cuihu Road, Kunming 650091, China.
Abstract:
A three-component Minisci reaction coupling of 1,3-dicarbonyl compounds with vinyl ethers and quinolines or isoquinolines under visible light is developed. The 1,3-dicarbonyl compound undergoes single-electron oxidation to afford an electrophilic 1,3-dicarbonyl radical under visible light irradiation. Due to the polarity of the free radical, the electrophilic radical adds to the electron-rich olefin to afford the nucleophilic radical. It coupled with the heteroarene to afford the three-component coupling products.
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