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Related Concept Videos

Infertility in Males01:23

Infertility in Males

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Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
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Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
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Updated: Dec 26, 2025

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis
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Male alcohol consumption and fecundability.

S Høyer1, A H Riis1, G Toft1

  • 1Department of Clinical Epidemiology, Aarhus University Hospital, 8200 Aarhus N, Denmark.

Human Reproduction (Oxford, England)
|March 11, 2020
PubMed
Summary
This summary is machine-generated.

This study found little evidence that male alcohol consumption reduces fecundability. While pooled data showed no significant association, the Danish cohort suggested a potential weak link with higher intake.

Keywords:
alcoholfecundabilityinfertilitymale fertilitytime to pregnancy

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Area of Science:

  • Reproductive Health
  • Epidemiology
  • Men's Health

Background:

  • Alcohol's impact on male reproductive physiology is known, affecting hormones and spermatogenesis.
  • However, limited epidemiological data exist on alcohol consumption and male fertility.

Purpose of the Study:

  • To investigate the association between male alcohol consumption and fecundability.
  • To analyze data from large preconception cohort studies in Denmark and North America.

Main Methods:

  • Prospective cohort design involving 2,679 couples from the SnartForaeldre (SF) and Pregnancy Study Online (PRESTO) studies.
  • Self-reported alcohol consumption categorized into standard servings per week; fecundability ratios (FRs) calculated using proportional probability regression.
  • Analyses adjusted for multiple covariates including age, female alcohol consumption, intercourse frequency, and lifestyle factors.

Main Results:

  • Pooled analysis revealed no significant association between male alcohol consumption (1-5, 6-13, or ≥14 servings/week) and reduced fecundability.
  • The Danish (SF) cohort showed a potential weak inverse association at higher consumption levels (≥6 servings/week).
  • The North American (PRESTO) cohort indicated a possible positive association with moderate consumption (6-13 servings/week).

Conclusions:

  • Overall, little evidence suggests male alcohol consumption significantly reduces fecundability.
  • Potential cohort-specific differences warrant further investigation, particularly regarding higher alcohol intake.
  • Limitations include baseline alcohol assessment and lack of binge drinking data.