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Related Concept Videos

Cytoskeletal Linker Proteins - Plakins01:09

Cytoskeletal Linker Proteins - Plakins

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Plakins are large proteins with binding domains for microtubules, microfilaments, intermediate filaments, and membrane-associated protein complexes at cell junctions. Plakin functions are evolutionarily conserved and are primarily involved in organizing the different components of the cytoskeleton by crosslinking them to each other and connecting them to the cell-matrix and cell adhesion complexes. They are also known to interact with signal transducers, serve as scaffolds for signaling...
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Tight junctions are molecular seals between cells that prevent the leaking of fluids, ions, and other small solutes across cavities and compartments in multicellular organisms. They are mainly composed of claudin and occludin transmembrane proteins, and other proteins such as tricellulin and JAM (junctional adhesion molecule). All these proteins are 4-pass transmembrane proteins, except JAM, which is a single-pass transmembrane protein belonging to the immunoglobulin superfamily. The...
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Enzymes like flippase, floppase, and scramblase transfer phospholipids from one layer to another in the membrane, thereby affecting membrane asymmetry.
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Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...
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Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
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Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
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Updated: Dec 26, 2025

Nanopodia - Thin, Fragile Membrane Projections with Roles in Cell Movement and Intercellular Interactions
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Tetraspanins.

Thorsten Lang1, Nikolas Hochheimer1

  • 1Department of Membrane Biochemistry, Life & Medical Sciences (LIMES) Institute, University of Bonn, Carl-Troll-Straße 31, 53115 Bonn, Germany.

Current Biology : CB
|March 11, 2020
PubMed
Summary
This summary is machine-generated.

Tetraspanins are proteins with crucial physiological roles. This study explores their involvement in various pathological conditions, highlighting their complex functions in disease.

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Immunology

Background:

  • Tetraspanins are a family of transmembrane proteins.
  • They play roles in cell signaling, adhesion, and immune responses.

Purpose of the Study:

  • To review the physiological functions of tetraspanins.
  • To discuss the pathological roles of tetraspanins in disease.

Main Methods:

  • Literature review of tetraspanin research.
  • Analysis of existing data on tetraspanin expression and function.

Main Results:

  • Tetraspanins are involved in diverse cellular processes.
  • Dysregulation of tetraspanins is linked to various diseases, including cancer and infections.

Conclusions:

  • Tetraspanins are critical regulators of cell function.
  • Targeting tetraspanins may offer therapeutic strategies for diseases.